LIG4 polyclonal antibody
产品名称： LIG4 polyclonal antibody
英文名称： LIG4 polyclonal antibody
产品编号： PAB17316
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of LIG4.
- Immunogen:
- A synthetic peptide corresponding to internal of human LIG4.
- Host:
- Rabbit
- Reactivity:
- Human
- Specificity:
- This antibody detects endogenous levels of total LIG4 protein.
- Form:
- Liquid
- Storage Buffer:
- In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Immunohistochemistry (1:50-1:100)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The DNA sequence and analysis of human chromosome 13.
Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, DuNature. 2004 Apr 1;428(6982):522-8.
- 2.
- DNA ligase IV from HeLa cell nuclei.
Robins P, Lindahl T.J Biol Chem. 1996 Sep 27;271(39):24257-61.
- 3.
- Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination.
Wei YF, Robins P, Carter K, Caldecott K, Pappin DJ, Yu GL, Wang RP, Shell BK, Nash RA, Schar P, et al..Mol Cell Biol. 1995 Jun;15(6):3206-16.
- Entrez GeneID:
- 3981
- Protein Accession#:
- P49917
- Gene Name:
- LIG4
- Gene Alias:
- -
- Gene Description:
- ligase IV, DNA, ATP-dependent
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq
- Other Designations:
- DNA joinase,DNA ligase IV,DNA repair enzyme,polydeoxyribonucleotide synthase [ATP] 4,polynucleotide ligase,sealase
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Ascariasis
- Asthma
- Asthma
- Ataxia telangiectasia
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma, Basal Cell
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Papillary
- Carcinoma, Squamous Cell
- Colorectal Neoplasms
- DNA Damage
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Genomic Instability
- Glioma
- Head and Neck Neoplasms