TARDBP polyclonal antibody
产品名称： TARDBP polyclonal antibody
英文名称： TARDBP polyclonal antibody
产品编号： PAB13283
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TARDBP.
- Immunogen:
- A synthetic peptide corresponding to 15 amino acids near C-terminus of human TARDBP.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- At least two isoforms are known to exist for this protein; this TDP43 antibody will recognize both isoforms.
- Form:
- Liquid
- Purification:
- Peptide affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-2 ug/mL)
Immunocytochemistry (5 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, Feiden W, Kretzschmar HA, Trojanowski JQ, Lee VM.Science. 2006 Oct 6;314(5796):130-3.
- 2.
- Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping.
Buratti E, Dork T, Zuccato E, Pagani F, Romano M, Baralle FE.EMBO J. 2001 Apr 2;20(7):1774-84.
- 3.
- Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs.
Ou SH, Wu F, Harrich D, Garcia-Martinez LF, Gaynor RB.J Virol. 1995 Jun;69(6):3584-96.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of TARDBP in HeLa cell lysate with TARDBP polyclonal antibody (Cat # PAB13283) at (A) 0.5, (B) 1 and (C) 2 ug/mL .
- Entrez GeneID:
- 23435
- Protein Accession#:
- ABO32290
- Gene Name:
- TARDBP
- Gene Alias:
- ALS10,TDP-43
- Gene Description:
- TAR DNA binding protein
- Omim ID:
- 605078
- Gene Ontology:
- Hyperlink
- Gene Summary:
- HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq
- Other Designations:
- OTTHUMP00000002171,TAR DNA-binding protein-43