MAP2K3 (phospho S189) Peptide
产品名称： MAP2K3 (phospho S189) Peptide
英文名称： MAP2K3 (phospho S189) Peptide
产品编号： P1494
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAP2K3.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S189 of human MAP2K3.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.
Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ.Oncogene. 2003 Sep 18;22(40):6129-41.
- 2.
- Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3.
Edlund S, Bu S, Schuster N, Aspenstrom P, Heuchel R, Heldin NE, ten Dijke P, Heldin CH, Landstrom M.Mol Biol Cell. 2003 Feb;14(2):529-44.
- 3.
- Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha.
Lim S, Jin K, Friedman E.J Biol Chem. 2002 Jul 12;277(28):25040-6. Epub 2002 Apr 29.
- Applications
- Dot Blot (Peptide)
- Dot blot analysis of MAP2K3 (phospho S189) polyclonal antibody (Cat # PAB0510) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration was 0.5 ug/mL. P-Pab : phospho-antibody; P-Peptide : phospho-peptide; NP-Peptide : non-phospho-peptide.
- Entrez GeneID:
- 5606
- Protein Accession#:
- NP_002747;P46734
- Gene Name:
- MAP2K3
- Gene Alias:
- MAPKK3,MEK3,MKK3,PRKMK3
- Gene Description:
- mitogen-activated protein kinase kinase 3
- Omim ID:
- 602315
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq
- Other Designations:
- MAP kinase kinase 3,MAPK/ERK kinase 3,OTTHUMP00000166044,dual specificity mitogen activated protein kinase kinase 3