ERBB2 (phospho Y877) polyclonal antibody
产品名称： ERBB2 (phospho Y877) polyclonal antibody
英文名称： ERBB2 (phospho Y877) polyclonal antibody
产品编号： PAB25294
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of ERBB2.
- Immunogen:
- Synthetic phosphopeptide corresponding to residues surrounding Y877 of human ERBB2.
- Sequence:
- T-E-Yp-H-A
- Host:
- Rabbit
- Theoretical MW (kDa):
- 185
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Purification:
- Affinity chromatography
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
Immunofluorescence (1:100-1:200)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from MDA-MB-231 cells treated or untreated with EGF using ERBB2 (phospho Y877) polyclonal antibody (Cat # PAB25294).
- Entrez GeneID:
- 2064
- Protein Accession#:
- P04626
- Gene Name:
- ERBB2
- Gene Alias:
- CD340,HER-2,HER-2/neu,HER2,NEU,NGL,TKR1
- Gene Description:
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq
- Other Designations:
- c-erb B2/neu protein,erbB-2,herstatin,neuroblastoma/glioblastoma derived oncogene homolog,v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
- Interactome
- Related Disease
- Adenocarcinoma
- Ataxia telangiectasia
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Adenosquamous
- Carcinoma, Ductal
- Carcinoma, Ductal, Breast
- Carcinoma, Intraductal, Noninfiltrating
- Carcinoma, Large Cell
- Carcinoma, Lobular
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cell Transformation, Neoplastic
- Cleft Lip
- Cleft Palate
- Colorectal Neoplasms
- Disease Progression