IRF3 (Human) Recombinant Protein (P01)
产品名称： IRF3 (Human) Recombinant Protein (P01)
英文名称： IRF3 (Human) Recombinant Protein (P01)
产品编号： H00003661-P01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human IRF3 full-length ORF ( AAH09395, 1 a.a. - 452 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALSRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKGKEGGVFDLGPFIVGSWAPRSDYLHGRKRTLTTLCPLVLCGGVMAPGPAVDQEARDGQGCAHVPQGLGRNGPGRGCLLPGEYCGPAHFQQPPTLPHLRPVQGLPAGLGGGHGFPGPWGDLSPRSSWCASNPPVPHHLNQ
- Theoretical MW (kDa):
- 75.24
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Publication Reference
- 1.
- NEMO Binds Ubiquitinated TANK-Binding Kinase 1 (TBK1) to Regulate Innate Immune Responses to RNA Viruses.
Wang L, Li S, Dorf ME.PLoS One. 2012;7(9):e43756. doi: 10.1371/journal.pone.0043756. Epub 2012 Sep 18.
- 2.
- Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3?PTANK?PTBK1/IKK{epsilon} Complex.
Siu KL, Kok KH, Ng MH, Poon VK, Yuen KY, Zheng BJ, Jin DY.J Biol Chem. 2009 Jun 12;284(24):16202-9. Epub 2009 Apr 20.
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 3661
- GeneBank Accession#:
- BC009395
- Protein Accession#:
- AAH09395
- Gene Name:
- IRF3
- Gene Alias:
- -
- Gene Description:
- interferon regulatory factor 3
- Omim ID:
- 603734
- Gene Ontology:
- Hyperlink
- Gene Summary:
- IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. [provided by RefSeq
- Other Designations:
- -
- Gene Pathway
- Related Disease
- Asthma
- Asthma
- Bronchiolitis, Viral
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Disease Progression
- Edema
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Hepatitis C
- Hepatitis C, Chronic
- Infant, Premature, Diseases
- Liver Cirrhosis
- Lung Neoplasms
- Lupus Erythematosus, Systemic
- Neutropenia
- Papillomavirus Infections
- Pulmonary Disease, Chronic Obstructive
- Respiratory Syncytial Virus Infections