RAF1 (phospho Y340) Peptide
产品名称： RAF1 (phospho Y340) Peptide
英文名称： RAF1 (phospho Y340) Peptide
产品编号： P1580
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of RAF1.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y340 of human RAF1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Peptide affinity purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis.
Dasgupta P, Sun J, Wang S, Fusaro G, Betts V, Padmanabhan J, Sebti SM, Chellappan SP.Mol Cell Biol. 2004 Nov;24(21):9527-41.
- 2.
- Raf-1 activation disrupts its binding to keratins during cell stress.
Ku NO, Fu H, Omary MB.J Cell Biol. 2004 Aug 16;166(4):479-85.
- 3.
- Change in protein flexibility upon complex formation: analysis of Ras-Raf using molecular dynamics and a molecular framework approach.
Gohlke H, Kuhn LA, Case DA.Proteins. 2004 Aug 1;56(2):322-37.
- Entrez GeneID:
- 5894
- Protein Accession#:
- NP_002871;P04049
- Gene Name:
- RAF1
- Gene Alias:
- CRAF,NS5,Raf-1,c-Raf
- Gene Description:
- v-raf-1 murine leukemia viral oncogene homolog 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq
- Other Designations:
- Oncogene RAF1,raf proto-oncogene serine/threonine protein kinase
- Interactome
- Gene Pathway
- Acute myeloid leukemia
- B cell receptor signaling pathway
- Bladder cancer
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- Gap junction
- Glioma
- GnRH signaling pathway
- Insulin signaling pathway
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- T cell receptor signaling pathway
- Vascular smooth muscle contraction
- VEGF signaling pathway
- Related Disease
- Abnormalities, Multiple
- Arrhythmias, Cardiac
- Articulation Disorders
- Cardiovascular Diseases
- Cognition
- Cognition Disorders
- Developmental Disabilities
- Diabetes Mellitus, Type 2
- Dyslexia, Acquired
- Edema
- Genetic Predisposition to Disease
- Glioma
- Hearing
- Heart Defects, Congenital
- Hypertrophy, Left Ventricular
- Language Disorders
- LEOPARD Syndrome
- Memory
- Motor Skills