F10 monoclonal antibody
产品名称： F10 monoclonal antibody
英文名称： F10 monoclonal antibody
产品编号： MAB0265
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native F10.
- Immunogen:
- Native purified Human F10.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- This antibody recognizes heavy chains of human factors Xa and X; does not bind bovine factor X or BEGRck-Xa. Inhibits PT, prothrombinase and partially APTT, but not amidase activity.
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (50% glycerol)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (5 ug/mL)
The optimal working dilution should be determined by the end user.
- Application Image
- Western Blot
- ELISA
- Entrez GeneID:
- 2159
- Gene Name:
- F10
- Gene Alias:
- FX,FXA
- Gene Description:
- coagulation factor X
- Omim ID:
- 227600
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq
- Other Designations:
- OTTHUMP00000018735,Stuart-Prower factor,factor Xa,prothrombinase
- Gene Pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Cardiovascular Diseases
- Cerebral Hemorrhage
- Chronic Disease
- Diabetes Complications
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Hypertension
- Intracranial Hemorrhages
- Kidney Diseases
- Kidney Failure, Chronic
- Metabolic Syndrome X
- Neoplasms
- Osteoporosis
- Premature Birth
- Stroke
- Subarachnoid Hemorrhage