CDKN1A monoclonal antibody, clone WA-1
产品名称: CDKN1A monoclonal antibody, clone WA-1
英文名称: CDKN1A monoclonal antibody, clone WA-1
产品编号: MAB0928
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native CDKN1A.
- Immunogen:
- Native purified human CDKN1A.
- Host:
- Mouse
- Reactivity:
- Human, Primates
- Form:
- Liquid
- Concentration:
- 1 mg/mL
- Isotype:
- IgG1
- Storage Buffer:
- In PBS, pH 7.4 (15 mM sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry staining of human colon carcinoma (paraffin - embedded sections) with CDKN1A monoclonal antibody, clone WA - 1 (Cat # MAB0928) .
- Entrez GeneID:
- 1026
- Gene Name:
- CDKN1A
- Gene Alias:
- CAP20,CDKN1,CIP1,MDA-6,P21,SDI1,WAF1,p21CIP1
- Gene Description:
- cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- Omim ID:
- 116899
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq
- Other Designations:
- CDK-interaction protein 1,DNA synthesis inhibitor,OTTHUMP00000016298,cyclin-dependent kinase inhibitor 1A,melanoma differentiation associated protein 6,wild-type p53-activated fragment 1
- Interactome
- Related Disease
- Adenocarcinoma
- Ataxia telangiectasia
- Atherosclerosis
- Atherosclerosis
- Bowen's Disease
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Basal Cell
- Carcinoma, Squamous Cell
- Carcinoma, Transitional Cell
- Cardiovascular Diseases
- Chromosome Aberrations
- Chronic Disease
- Colorectal Neoplasms
- Diabetes Mellitus, Type 2
- Disease Progression
- DNA Damage