HFE2 polyclonal antibody (A01)
产品名称： HFE2 polyclonal antibody (A01)
英文名称： HFE2 polyclonal antibody (A01)
产品编号： H00148738-A01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a partial recombinant HFE2.
- Immunogen:
- HFE2 (NP_973733, 93 a.a. ~ 173 a.a) partial recombinant protein with GST tag.
- Sequence:
- GGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPS
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- 50 % glycerol
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (35.02 KDa) .
- MSDS:
Download
- Publication Reference
- 1.
- Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors: NEW LINK BETWEEN HYPOXIA SIGNALING AND IRON HOMEOSTASIS.
Lakhal S, Schodel J, Townsend AR, Pugh CW, Ratcliffe PJ, Mole DR.J Biol Chem. 2011 Feb 11;286(6):4090-7. Epub 2010 Oct 21.
- Applications
- Western Blot (Cell lysate)
- HFE2 polyclonal antibody (A01), Lot # 060519JCS1 Western Blot analysis of HFE2 expression in U-2 OS ( Cat # L022V1 ).
- Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Entrez GeneID:
- 148738
- GeneBank Accession#:
- NM_202004
- Protein Accession#:
- NP_973733
- Gene Name:
- HFE2
- Gene Alias:
- HFE2A,HJV,JH,MGC23953,RGMC
- Gene Description:
- hemochromatosis type 2 (juvenile)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq
- Other Designations:
- OTTHUMP00000015582,OTTHUMP00000015583,OTTHUMP00000059680,RGM domain family, member C,hemochromatosis type 2 protein,hemojuvelin
- Related Disease