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Piclidenoson
CAS No. : 152918-18-8
MCE 国际站：Piclidenoson
产品活性：Piclidenoson (IB-MECA) 是一种首创的，具有口服活性的，选择性的腺苷 A3 受体 (A3AR) 激动剂。Piclidenoson 在不同类型的癌细胞如黑色素瘤、白血病中表现出抗增殖和诱导凋亡 (apoptosis) 的作用。Piclidenoson 可用于自身免疫性炎症疾病和 COVID-19 的研究。
研究领域：GPCR/G Protein | Apoptosis
作用靶点：Adenosine Receptor | Apoptosis
In Vitro: Piclidenoson is able to inhibit Forskolin (HY-15371)-stimulated cAMP levels with EC50s of 0.82 μM and 1.2 μM in OVCAR-3 cells and Caov-4 cells, respectively.
?Piclidenoson (0.0001-100 μM; 48 hours) significantly reduces cell viability in a dose-dependent manner in human ovarian cancer cell lines, with IC50s of 32.14 μM and 45.37 μM for OVCAR-3 and Caov-4 cells, respectively.
?Piclidenoson (0.001-100 μM; 48 hours) induces apoptosis in ovarian cancer cell line through the caspase pathway.
?Piclidenoson induces apoptosis via the mitochondrial signaling pathway.
In Vivo: Piclidenoson (105 μg/kg; i.p.) enhances survival of γ-irradiated mice.
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